Full Form of KHK

What is KHK?

Ketohexokinase (KHK) is an enzyme encoded by the KHK gene in humans, primarily involved in the metabolism of fructose. It catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as a phosphate donor. This reaction is the first step in the major pathway for fructose utilization in the liver, kidneys, and intestine. In the Indian medical education system, KHK is a key topic in biochemistry curricula for undergraduate and postgraduate students, especially those preparing for competitive exams like NEET PG, AIIMS, and USMLE. Understanding KHK is crucial because its deficiency leads to essential fructosuria, a benign condition where fructose is excreted in urine, while excessive activity has been linked to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The enzyme is also studied in the context of dietary fructose absorption and its role in the pathogenesis of obesity and diabetes. Clinically, KHK levels or activity can be measured in research settings, though routine diagnostic tests are uncommon. For Indian students, this enzyme appears in questions on carbohydrate metabolism, enzyme kinetics, and inherited metabolic disorders. Mastery of KHK and its regulatory mechanisms is essential for scoring high in medical entrance examinations and for clinical practice.

KHK का फुल फॉर्म

Example

During the biochemistry viva, the professor asked about the role of KHK in fructose metabolism and its association with essential fructosuria.

KHK — frequently asked questions

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