Full formScience
CHFRstands forCheckpoint with Forkhead-associated and RING Finger Domains
Full Form of CHFR
What is CHFR?
CHFR stands for Checkpoint with Forkhead-associated and RING Finger Domains, a protein-coding gene that plays a critical role in regulating the cell cycle, particularly during the early prophase stage of mitotic division. It functions as an E3 ubiquitin ligase and acts as a tumour suppressor by delaying chromosome condensation in response to mitotic stress, thereby helping cells repair DNA damage before proceeding with division. In Indian biomedical research, CHFR is widely studied in the context of cancer biology, with researchers at premier institutions like the Indian Institute of Science Bangalore, Tata Memorial Centre Mumbai, and AIIMS New Delhi actively investigating its epigenetic silencing and promoter methylation patterns in various cancers including gastric, colorectal, lung, and breast cancers. The gene encoding this protein is often found to be hypermethylated and epigenetically silenced in many tumour types, making it a significant diagnostic and prognostic biomarker in oncology. Understanding CHFR is particularly relevant for students preparing for competitive examinations such as CSIR-NET Life Sciences, GATE Biotechnology, DBT-JRF, and ICMR JRF, where molecular biology, cell signalling, and cancer genetics form important portions of the syllabus. Its central role in the DNA damage response pathway also connects it to broader concepts of genomic stability, chemotherapy response, and oncogenesis research.
CHFR का फुल फॉर्म
फोर्कहेड-एसोसिएटेड और रिंग फिंगर डोमेन युक्त चेकपॉइंट
Example
Researchers at the Indian Institute of Science Bangalore recently published findings on CHFR promoter methylation as a potential biomarker for early detection of gastric cancer in Indian patients.
CHFR — frequently asked questions
What is the full form of CHFR?
CHFR stands for Checkpoint with Forkhead-associated and RING Finger Domains, a protein involved in cell cycle regulation and tumour suppression.
What is the function of CHFR protein?
CHFR is an E3 ubiquitin ligase that acts as a tumour suppressor by delaying chromosome condensation during the early prophase checkpoint, allowing cells to repair DNA damage before dividing.
CHFR is associated with which type of cancer?
CHFR silencing through promoter hypermethylation has been observed in several cancers including gastric, colorectal, lung, and breast cancers, making it a useful diagnostic biomarker.